Article
CARD15 variants in patients with sporadic Parkinson's disease.
Neuroscience research - 1 Mar 2007
Bialecka Monika, Kurzawski Mateusz, Klodowska-Duda Gabriela, Opala Grzegorz, Juzwiak Stefania, Kurzawski Grzegorz, Tan Eng-King, Drozdzik Marek
Abstract excerpt
Recent reports have proven the importance of genetic factors and inflammation in the pathogenesis of sporadic Parkinson's disease (PD). In the current study, the frequency of CARD15/NOD2 gene variants (R702W, G908R, L1007fs), previously associated with Crohn's disease--a common inflammatory bowel disease, have been examined in a group of 308 sporadic PD patients and 220 healthy controls. Significantly higher...
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