Article
Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies Report of the BIOMED-2 Concerted Action BHM4 CT98-3936.
Leukemia - 1 Feb 2007
Brüggemann M, White H, Gaulard P, Garcia-Sanz R, Gameiro P, Oeschger S, Jasani B, Ott M, Delsol G, Orfao A, Tiemann M, Herbst H, Langerak A W, Spaargaren M, Moreau E, Groenen P J T A, Sambade C, Foroni L, Carter G I, Hummel M, Bastard C, Davi F, Delfau-Larue M-H, Kneba M, van Dongen J J M, Beldjord K, Molina T J
Abstract excerpt
Polymerase chain reaction (PCR) assessment of clonal T-cell receptor (TCR) and immunoglobulin (Ig) gene rearrangements is an important diagnostic tool in mature T-cell neoplasms. However, lack of standardized primers and PCR protocols has hampered comparability of data in previous clonality studies. To obtain reference values for Ig/TCR rearrangement patterns, 19 European laboratories investigated 188 T-cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.