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Mitochondrial function, fibre types and ageing: new insights from human muscle in vivo

15 Dec 2006

Abstract excerpt

Mitochondrial changes are at the centre of a wide range of maladies, including diabetes, neurodegeneration and ageing-related dysfunctions. Here we describe innovative optical and magnetic resonance spectroscopic methods that non-invasively measure key mitochondrial fluxes, ATP synthesis and O(2) uptake, to permit the determination of mitochondrial coupling efficiency in vivo (P/O: half the ratio of ATP flux to...

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PMID: 17170059
DOI: 10.1113/expphysiol.2006.034330

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