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Marked aging‐related decline in efficiency of oxidative phosphorylation in human skin fibroblasts

18 Jul 2003

Abstract excerpt

An extensive analysis has been carried out of mitochondrial biochemical and bioenergetic properties of fibroblasts, mostly skin-derived, from a large group of subjects ranging in age between 20 wk fetal and 103 yr. A striking age-related change observed in a fundamental process underlying mitochondrial biogenesis and function was the very significant decrease in rate of mitochondrial protein synthesis in...

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PMID: 12958183
DOI: 10.1096/fj.02-1009fje

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