Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutating the anchor residues associated with MHC binding inhibits and deviates CD8+ T cell mediated protective immunity against malaria.

Molecular immunology - 1 Mar 2007

Dobaño C, McTague A, Sette A, Hoffman S L, Rogers W O, Doolan D L

Abstract excerpt

We investigated whether immune responses induced by immunization with plasmid DNA are restricted predominantly to immunodominant CD8+ T cell epitopes, or are raised against a breadth of epitopes including subdominant CD8+ and CD4+ T cell epitopes. Site-directed mutagenesis was used to change one or more primary anchor residues of the immunodominant CD8+ T cell epitope on the Plasmodium yoelii circumsporozoite...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Affinity
Share to Antibody Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Protozoan

Share to DNA, Protozoan

Share to Immunity

Share to Immunodominant Epitopes

Share to Malaria

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 17169429
DOI: 10.1016/j.molimm.2006.11.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutating the anchor residues associated with MHC binding inhibits and deviates CD8+ T cell mediated protective immunity against malaria.PMID 17169429Read ↗

Are extensive T cell epitope polymorphisms in the Plasmodium falciparum circumsporozoite antigen, a leading sporozoite vaccine candidate, selected by immune pressure?Semantic proximity Read ↗

A CD8 T-cell epitope variant enhances immune targeting to a recombinant picornavirus vaccine antigen.Semantic proximity Read ↗

Importance of the Immunodominant CD8 + T Cell Epitope of Plasmodium berghei Circumsporozoite Protein in Parasite- and Vaccine-Induced ProtectionSemantic proximity Read ↗

New Candidate Vaccines against Blood-StagePlasmodium falciparumMalaria: Prime-Boost Immunization Regimens Incorporating Human and Simian Adenoviral Vectors and Poxviral Vectors Expressing an Optimized Antigen Based on Merozoite Surface Protein 1Semantic proximity Read ↗

Cytotoxic T cell reactivity and HLA-B35 binding of the variant Plasmodium falciparum circumsporozoite protein CD8+ CTL epitope in naturally exposed Kenyan adults.Semantic proximity Read ↗

Protection fromPlasmodium berghei infection by priming and boosting T cells to a single class I-restricted epitope with recombinant carriers suitable for human useSemantic proximity Read ↗

A strong CD8+ T cell response is elicited using the synthetic polypeptide from the C-terminus of the circumsporozoite protein of Plasmodium berghei together with the adjuvant QS-21: quantitative and phenotypic comparison with the vaccine model of irradiated sporozoites.Semantic proximity Read ↗

B-cell responses to a peptide epitope: mutations in heavy chain alone lead to maturation of antibody responses.Semantic proximity Read ↗

Vaccine Containing the Three Allelic Variants of the Plasmodium vivax Circumsporozoite Antigen Induces Protection in Mice after Challenge with a Transgenic Rodent Malaria ParasiteSemantic proximity Read ↗

Lipopeptide immunization without adjuvant induces potent and long‐lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzeesSemantic proximity Read ↗

Synthetic malaria peptide vaccine elicits high levels of antibodies in vaccinees of defined HLA genotypes.Semantic proximity Read ↗

Human and murine T-cell responses to allelic forms of a malaria circumsporozoite protein epitope support a polyvalent vaccine strategy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.