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Protection fromPlasmodium berghei infection by priming and boosting T cells to a single class I-restricted epitope with recombinant carriers suitable for human use

1 Dec 1998

Abstract excerpt

The desirability of inducing cytotoxic T cell responses to defined epitopes in humans has led to the development of a variety of recombinant delivery systems. Recombinant protein particles derived from a yeast retrotransposon (Ty) and the modified Ankara vaccinia (MVA) virus can deliver large epitope strings or even whole proteins. Both have previously been administered safely in humans. Immunization with...

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PMID: 9862371
DOI: 10.1002/(sici)1521-4141(199812)28:12<4345::aid-immu4345>3.0.co;2-p

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