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Intestinal Epithelial C/EBPβ Deficiency Impairs Colitis-Associated Tumorigenesis by Disrupting CXCL1/CXCL2/CXCL5-CXCR2-Mediated Neutrophil Infiltration

2025-06-27

Abstract excerpt

Dysregulated transcription factors critically link chronic inflammation to oncogenesis in colitis-associated colorectal cancer (CAC), but their mechanistic roles remain incompletely understood. By integrating microarray and transcriptome sequencing data from ulcerative colitis (UC), colitis-associated cancer (CAC), and colorectal cancer (CRC) patients, we identify C/EBPβ as a key transcriptional regulator whose el...

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Literature Corpus work: 00b95325-61aa-5e27-80c6-71603b46119c
DOI: 10.1101/2025.06.25.661448

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Intestinal Epithelial C/EBPβ Deficiency Impairs Colitis-Associated Tumorigenesis by Disrupting CXCL1/CXCL2/CXCL5-CXCR2-Mediated Neutrophil InfiltrationDOI 10.1101/2025.06.25.661448Read

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