The IRF5 rs2004640 (G/T) polymorphism is not a genetic risk factor for systemic lupus erythematosus in population from south India.

doi:10.4103/ijmr.IJMR_2025_16

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Article

The IRF5 rs2004640 (G/T) polymorphism is not a genetic risk factor for systemic lupus erythematosus in population from south India.

The Indian journal of medical research - 1 Jun 2018

Devaraju Panneer, Mehra Sonal, Gulati Reena, Antony Paul T, Jain Vikramraj K, Misra Durga Prasanna, Negi Vir Singh

Abstract excerpt

Background & objectives: Genetic aberrations disrupting toll-like receptor and interferon homeostasis enhance the risk of systemic lupus erythematosus (SLE). Raised serum interferon-alpha (IFN-α) levels in SLE patients have been ascribed to polymorphism (rs2004640 G/T) in interferon regulatory factor 5 (IRF5) gene, resulting in enhanced transcript splicing. A positive association between IRF5 polymorphism and SLE...

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Identifiers

PMID: 30168487
DOI: 10.4103/ijmr.IJMR_2025_16
PMCID: PMC6118151

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