Genotype x adiposity interaction linkage analyses reveal a locus on chromosome 1 for lipoprotein-associated phospholipase A2, a marker of inflammation and oxidative stress.

doi:10.1086/510497

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Article

Genotype x adiposity interaction linkage analyses reveal a locus on chromosome 1 for lipoprotein-associated phospholipase A2, a marker of inflammation and oxidative stress.

American journal of human genetics - 1 Jan 2007

Diego Vincent P, Rainwater David L, Wang Xing-Li, Cole Shelley A, Curran Joanne E, Johnson Matthew P, Jowett Jeremy B M, Dyer Thomas D, Williams Jeff T, Moses Eric K, Comuzzie Anthony G, Maccluer Jean W, Mahaney Michael C, Blangero John

Abstract excerpt

Because obesity leads to a state of chronic, low-grade inflammation and oxidative stress, we hypothesized that the contribution of genes to variation in a biomarker of these two processes may be influenced by the degree of adiposity. We tested this hypothesis using samples from the San Antonio Family Heart Study that were assayed for activity of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), a marker of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17160904
DOI: 10.1086/510497
PMCID: PMC1785310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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