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Article

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX.

The EMBO journal - 10 Jan 2007

Uldrijan Stjepan, Pannekoek Willem-Jan, Vousden Karen H

Abstract excerpt

MDM2 (HDM2) is a ubiquitin ligase that can target the p53 tumor suppressor protein for degradation. The RING domain is essential for the E3 activity of MDM2, and we show here that the extreme C-terminal tail of MDM2 is also critical for efficient E3 activity. Loss of E3 function in MDM2 mutants deleted of the C-terminal tail correlated with a failure of these mutants to oligomerize with MDM2, or with the related...

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Source

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Identifiers

PMID: 17159902
DOI: 10.1038/sj.emboj.7601469
PMCID: PMC1782374

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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An essential function of the extreme C-terminus of MDM2 can be provided by MDMX.PMID 17159902Read ↗

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Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction.Semantic proximity Read ↗

Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells.Semantic proximity Read ↗

MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding.Semantic proximity Read ↗

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