Article
The neurofibroma in von Recklinghausen neurofibromatosis has a unicellular origin.
American journal of human genetics - 1 Sept 1991
Skuse G R, Kosciolek B A, Rowley P T
Abstract excerpt
von Recklinghausen neurofibromatosis (NF1) is the most common hereditary syndrome predisposing to neoplasia. NF1 is an autosomal dominant disease caused by a single gene which maps to chromosome 17q11.2. The most common symptomatic manifestation of NF1 is the benign neurofibroma. Our previous studies of tumors in NF1, studies which detected a loss of heterozygosity for DNA markers from the NF1 region of...
Topics
- Blotting, Southern
- Chromosomes, Human, Pair 17
- DNA Probes
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Female
- Heterozygote
- Humans
- Male
- Mutation
- Neurofibroma