Confirmation of a double-hit model for the NF1 gene in benign neurofibromas.

doi:10.1086/515504

Back to search

Article

Confirmation of a double-hit model for the NF1 gene in benign neurofibromas.

American journal of human genetics - 1 Sept 1997

Serra E, Puig S, Otero D, Gaona A, Kruyer H, Ars E, Estivill X, Lázaro C

Abstract excerpt

Neurofibroma is a benign tumor that arises from small or large nerves. This neoplastic lesion is a common feature of neurofibromatosis type 1 (NF1), one of the most common autosomal dominant disorders. The NF1 gene codes for a protein called "neurofibromin." It possesses a region that shares a hi...

Topics

Alleles
Chromosomes, Human, Pair 17
Female
Genes, Neurofibromatosis 1
Genetic Markers
Humans
Male
Mutation
Neurofibromatosis 1
Pedigree
Sequence Deletion

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.