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Article

DLG5 P1371Q is associated with inflammatory bowel disease and complementary to R30Q in disease susceptibility.

Swiss medical weekly - 1 Jan 2011

Lin Zhenwu, Hegarty John P, Berb Arthur, Wang Zhong, Kelly Ashley A, Wang Yunhua, Poritz Lisa S, Wu Rongling, Koltun Walter A

Abstract excerpt

BACKGROUND AND PURPOSE: The SNP R30Q (rs1248696) within the discs large homolog 5 (DLG5) gene has been associated with inflammatory bowel disease (IBD). In this study, we examined the genetic association of another DLG5 SNP P1371Q (rs2289310) with IBD and its interaction with R30Q in disease susceptibility. METHODS: A total of 213 IBD patients [106 familial; 59 Crohn's disease (CD) and 47 ulcerative colitis (UC)]...

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Source

Identifiers

PMID: 22065243
DOI: 10.4414/smw.2011.13290

Genes

DLG5

Variants

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Related research

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DLG5 P1371Q is associated with inflammatory bowel disease and complementary to R30Q in disease susceptibility.PMID 22065243Read ↗

Meta-analysis of associations between DLG5 R30Q and P1371Q polymorphisms and susceptibility to inflammatory bowel disease.Semantic proximity Read ↗

Association of DLG5 variants with inflammatory bowel disease in the New Zealand Caucasian population and meta-analysis of the DLG5 R30Q variant.Semantic proximity Read ↗

DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's disease.Semantic proximity Read ↗

Genetic association of DLG5 R30Q with familial and sporadic inflammatory bowel disease in men.Semantic proximity Read ↗

Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease.Semantic proximity Read ↗

Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men.Semantic proximity Read ↗

Role of discs large homolog 5.Semantic proximity Read ↗

The R30Q DLG5 variant is not associated with celiac disease or inflammatory bowel disease in the Spanish population.Semantic proximity Read ↗

Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population.Semantic proximity Read ↗

Association of DLG5 R30Q variant with inflammatory bowel disease.Semantic proximity Read ↗

Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohn's disease.Semantic proximity Read ↗

DLG5 variants in inflammatory bowel disease.Semantic proximity Read ↗

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