Article
Sympathetic modulation of the cardiac myocyte phenotype: studies with a cell-culture model of myocardial hypertrophy.
Basic research in cardiology - 1 Jan 1992
Long C S, Kariya K, Karns L, Simpson P C
Abstract excerpt
Myocardial hypertrophy is the common endpoint of many cardiovascular stimuli such as hypertension, myocardial infarction, valvular disease, and congestive failure. Catecholamines have long been implicated in the pathogenesis of myocardial hypertrophy, however, it is very difficult to sort out catecholamine mechanisms in vivo. We have developed a cell-culture model which excludes hemodynamic effects and allows the...
Topics
- Animals
- Cardiomegaly
- Catecholamines
- Cells, Cultured
- Contractile Proteins
- Growth Substances
- Isomerism
- Models, Cardiovascular
- Myocardium
- Phenotype
- Receptors, Adrenergic, alpha