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Article

The role of host PrP in Transmissible Spongiform Encephalopathies.

Biochimica et biophysica acta - 1 Jun 2007

Cancellotti Enrico, Barron Rona M, Bishop Matthew T, Hart Patricia, Wiseman Frances, Manson Jean C

Abstract excerpt

PrP has a central role in the Transmissible Spongiform Encephalopathies (TSEs), and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent. However, precisely how host PrP influences the outcome of disease has not been established. To investigate this we have produced by gene targeting a series of inbred lines of transgenic mice expressing different PrP genes. This...

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Identifiers

PMID: 17150338
DOI: 10.1016/j.bbadis.2006.10.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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