Article
[Molecular genetics of familial and sporadic forms of human prion diseases].
Annales pharmaceutiques francaises - 1 Jan 1995
Laplanche J L, Launay J M, Dreux C
Abstract excerpt
Prion diseases, also known as transmissible subacute spongiform encephalopathies (TSSE), are rare neurodegenerative disorders of both humans and animals. Their biochemical hallmark is an accumulation in the brain of an abnormal form of the host-encoded prion protein (PrP). This pathological accumulation could result from a protein conformational change under the influence of unknown factors. The normal function...
Topics
- Animals
- Codon
- Humans
- Minisatellite Repeats
- Molecular Biology
- Mutation
- Polymorphism, Genetic
- Prion Diseases
- Sequence Deletion