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Article

A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2012

Nordmann Alexandra, Wixler Ludmilla, Boergeling Yvonne, Wixler Viktor, Ludwig Stephan

Abstract excerpt

Guanylate-binding proteins (GBPs) belong to the family of large GTPases that are induced in response to interferons. GBPs contain an N-terminal globular GTPase domain and a C-terminal α-helical regulatory domain that are connected by a short middle domain. Antiviral activity against vesicular stomatitis virus and encephalomyocarditis virus has been shown for hGBP-1; however, no anti-influenza virus properties for...

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PMID: 22106366
DOI: 10.1096/fj.11-189886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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