Article
Beta2-adrenergic receptor and UCP3 variants modulate the relationship between age and type 2 diabetes mellitus.
BMC medical genetics - 6 Dec 2006
Pinelli Michele, Giacchetti Manuela, Acquaviva Fabio, Cocozza Sergio, Donnarumma Giovanna, Lapice Emanuela, Riccardi Gabriele, Romano Geremia, Vaccaro Olga, Monticelli Antonella
Abstract excerpt
BACKGROUND: It is widely accepted that Type 2 Diabetes Mellitus (T2DM) and other complex diseases are the product of complex interplay between genetic susceptibility and environmental causes. To cope with such a complexity, all the statistical and conceptual strategies available should be used. The working hypothesis of this study was that two well-known T2DM risk factors could have diverse effect in individuals...
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