Article
Neutralizing monoclonal antibodies against porcinophilic foot-and-mouth disease virus mapped to antigenic site 2 by utilizing novel mutagenic virus-like particles to detect the antigenic change.
Veterinary microbiology - 1 Aug 2018
Lee Heng-Wei, Deng Ming-Chung, Pan Chu-Hsiang, Chang Hui-Wen, Cheng Ivan-Chen
Abstract excerpt
In the case of serotype O foot-and-mouth disease virus (FMDV), antibodies against five neutralizing sites play a pivotal role in protection of animals, with site 1 being considered the most crucial. However, recent studies indicated that the antibodies of vaccinated farm animals are mainly against site 2 rather than site 1. In Taiwan, blanket vaccination had been implemented for more than fifteen years, in which...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Neutralizing
- Antibodies, Viral
- Antigens, Viral
- Epitopes
- Foot-and-Mouth Disease
- Foot-and-Mouth Disease Virus
- Mutation
- Neutralization Tests
- Swine
- Swine Diseases
- Taiwan