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Article

Naturally occurring human parainfluenza type 3 viruses exhibit divergence in amino acid sequence of their fusion protein neutralization epitopes and cleavage sites.

Journal of virology - 1 Mar 1990

Coelingh K V, Winter C C

Abstract excerpt

Many human parainfluenza type 3 virus (PIV3) strains isolated from children with respiratory illness are resistant to neutralization by monoclonal antibodies (MAbs) which recognize epitopes in antigenic site A or B of the fusion (F) protein of the prototype 1957 PIV3 strain. The F protein genes of seven PIV3 clinical isolates were sequenced to determine whether their neutralization-resistant phenotypes were...

Topics

Amino Acid Sequence
Animals
Cell Line
Child
Epitopes
Genes, Viral
Genetic Variation
Humans
Macaca mulatta
Neutralization Tests
Parainfluenza Virus 3, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Respiratory Tract Infections

Respirovirus

Viral Fusion Proteins

Viral Structural Proteins

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1689394
DOI: 10.1128/JVI.64.3.1329-1334.1990
PMCID: PMC249251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1689394-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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