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Article

Genetic and epigenetic analysis of CHEK2 in sporadic breast, colon, and ovarian cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2006

Williams Louise H, Choong David, Johnson Sandra A, Campbell Ian G

Abstract excerpt

PURPOSE: Germ-line variants in CHEK2 have been associated with increased breast, thyroid, prostate, kidney, and colorectal cancer risk; however, the prevalence of somatic inactivation of CHEK2 in common cancer types is less clear. The aim of this study was to determine if somatic mutation and/or epigenetic modification play a role in development of sporadic breast, colon, or ovarian cancers. EXPERIMENTAL DESIGN:...

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Share to Chromosomes, Human, Pair 22

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

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Source

Identifiers

PMID: 17145815
DOI: 10.1158/1078-0432.CCR-06-1770

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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