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Further Association of Germline CHEK2 Loss-of-Function Variants with Testicular Germ Cell Tumors

13 Nov 2023

Abstract excerpt

Testicular germ cell tumors (TGCTs) represent the most frequent malignancy in young adult men and have one the highest heritability rates among all cancers. A recent multicenter case–control study identified CHEK2 as the first moderate-penetrance TGCT predisposition gene. Here, we analyzed CHEK2 in 129 TGCT cases unselected for age of onset, histology, clinical outcome, and family history of any cancer, and the...

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PMID: 38002677
DOI: 10.3390/jcm12227065

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Further Association of Germline CHEK2 Loss-of-Function Variants with Testicular Germ Cell TumorsPMID 38002677Read ↗

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