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Article

Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor.

Molecular and cellular biology - 1 Feb 2007

Yang Li V, Radu Caius G, Roy Meenakshi, Lee Sunyoung, McLaughlin Jami, Teitell Michael A, Iruela-Arispe M Luisa, Witte Owen N

Abstract excerpt

GPR4 is a G protein-coupled receptor expressed in the vasculature, lung, kidney, and other tissues. In vitro ectopic overexpression studies implicated GPR4 in sensing extracellular pH changes leading to cyclic AMP (cAMP) production. To investigate its biological roles in vivo, we generated GPR4-d...

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Source

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Identifiers

PMID: 17145776
DOI: 10.1128/MCB.01909-06
PMCID: PMC1800706

Genes

GPR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17145776-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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