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Article

GPRASP1 loss-of-function links to arteriovenous malformations by endothelial activating GPR4 signals

28 Sept 2023

Abstract excerpt

Arteriovenous malformations (AVMs) are fast-flow vascular malformations and refer to important causes of intracerebral haemorrhage in young adults. Getting deep insight into the genetic pathogenesis of AVMs is necessary. Herein, we identified two vital missense variants of G protein-coupled receptor (GPCR) associated sorting protein 1 (GPRASP1) in AVM patients for the first time and congruously determined to be...

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Share to Intracerebral and Subarachnoid Hemorrhage Research
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PMID: 37787182
DOI: 10.1093/brain/awad335

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