Article
Genome wide expression analysis of white blood cells and liver of pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats using a cDNA microarray.
Biological & pharmaceutical bulletin - 1 Dec 2006
Iida Shinya, Sato Yuichiro, Nakaya Akihiro, Shinohara Yasuo, Hayashi Yasuhiro, Sawada Akihiro, Nagata Hideya, Kaji Noritada, Kamiya Hiroyuki, Baba Yoshinobu, Harashima Hideyoshi
Abstract excerpt
In a prior study, we reported on a significant decrease in calpain10 gene expression in white blood cells (WBC) as well as the major insulin-target tissues including liver and adipose tissue, before the onset of diabetes in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. In this study, we extended our hypothesis that some type 2 diabetes mellitus (NIDDM) susceptible genes are up/down-regulated before the onset in...
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