Article
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.
Nature genetics - 1 Dec 2003
Tokuhiro Shinya, Yamada Ryo, Chang Xiaotian, Suzuki Akari, Kochi Yuta, Sawada Tetsuji, Suzuki Masakatsu, Nagasaki Miyuki, Ohtsuki Masahiko, Ono Mitsuru, Furukawa Hidehiko, Nagashima Masakazu, Yoshino Shinichi, Mabuchi Akihiko, Sekine Akihiro, Saito Susumu, Takahashi Atsushi, Tsunoda Tatsuhiko, Nakamura Yusuke, Yamamoto Kazuhiko
Abstract excerpt
Rheumatoid arthritis is a common inflammatory disease with complex genetic components. We investigated the genetic contribution of the cytokine gene cluster in chromosome 5q31 to susceptibility to rheumatoid arthritis in the Japanese population by case-control linkage disequilibrium (LD) mapping using single nucleotide polymorphisms (SNPs). Here we report that there is significant association between rheumatoid...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.