Article
YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7.
The Journal of biological chemistry - 2 Feb 2007
Pedelini Leda, Marquina Maribel, Ariño Joaquin, Casamayor Antonio, Sanz Libia, Bollen Mathieu, Sanz Pascual, Garcia-Gimeno Maria Adelaida
Abstract excerpt
We have recently characterized Ypi1 as an inhibitory subunit of yeast Glc7 PP1 protein phosphatase. In this work we demonstrate that Ypi1 forms a complex with Glc7 and Sds22, another Glc7 regulatory subunit that targets the phosphatase to substrates involved in cell cycle control. Interestingly, the combination of equimolar amounts of Ypi1 and Sds22 leads to an almost full inhibition of Glc7 activity. Because...
Topics
- Cell Nucleus
- DNA Primers
- Enzyme Inhibitors
- Escherichia coli
- Genotype
- Intracellular Signaling Peptides and Proteins
- Mitosis
- Molecular Sequence Data
- Nuclear Proteins
- Phosphoprotein Phosphatases