Article
Essential functions of Sds22p in chromosome stability and nuclear localization of PP1.
Journal of cell science - 1 Jan 2002
Peggie Mark W, MacKelvie Sarah H, Bloecher Andrew, Knatko Elena V, Tatchell Kelly, Stark Michael J R
Abstract excerpt
Sds22p is a conserved, leucine-rich repeat protein that interacts with the catalytic subunit of protein phosphatase 1 (PP1(C)) and which has been proposed to regulate one or more functions of PP1(C) during mitosis. Here we show that Saccharomyces cerevisiae Sds22p is a largely nuclear protein, most of which is present as a sTable 1:1 complex with yeast PP1(C) (Glc7p). Temperature-sensitive (Ts(-)) S. cerevisiae...
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