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Article

A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer.

Human molecular genetics - 1 Jun 2002

Rafii Saeed, O'Regan Paul, Xinarianos George, Azmy Iman, Stephenson Tim, Reed Malcolm, Meuth Mark, Thacker John, Cox Angela

Abstract excerpt

An acquired genetic instability, resulting from the loss of some types of DNA repair, is an early event in the development of a subset of human cancers. The involvement of BRCA1 and BRCA2 in the homologous recombination repair (HRR) of double-strand breaks in DNA implicates this pathway in the suppression of breast cancer. A family of proteins related to human RAD51, including XRCC2, are essential components of...

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Share to Polymorphism, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12023985
DOI: 10.1093/hmg/11.12.1433

Genes

XRCC2
BRCA1
BRCA2
RAD51

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer.PMID 12023985Read ↗

Association between XRCC2 Arg188His Polymorphism and Breast Cancer Susceptibility: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

XRCC2 Arg188His polymorphism is not directly associated with breast cancer risk: evidence from 37,369 subjects.Semantic proximity Read ↗

A role for XRCC2 gene polymorphisms in breast cancer risk and survival.Semantic proximity Read ↗

Impact of XRCC2 Arg188His polymorphism on cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage.Semantic proximity Read ↗

Variants in DNA double-strand break repair genes and breast cancer susceptibility.Semantic proximity Read ↗

Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses' Health Study.Semantic proximity Read ↗

Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk.Semantic proximity Read ↗

Arg188His polymorphism in the XRCC2 gene and the risk of ovarian cancer: a meta-analysis.Semantic proximity Read ↗

The Arg188His polymorphism in the XRCC2 gene and the risk of cancer.Semantic proximity Read ↗

The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1.Semantic proximity Read ↗

Polymorphisms in<i>RAD51, XRCC2</i>, and<i>XRCC3</i>Are Not Related to Breast Cancer RiskSemantic proximity Read ↗

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