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Article

Effect of ezetimibe coadministered with statins in genotype-confirmed heterozygous FH patients.

Atherosclerosis - 1 Oct 2007

Pisciotta Livia, Fasano Tommaso, Bellocchio Antonella, Bocchi Letizia, Sallo Raffaella, Fresa Raffaele, Colangeli Isabella, Cantafora Alfredo, Calandra Sebastiano, Bertolini Stefano

Abstract excerpt

We investigated the effect of statins and statins plus ezetimibe in 65 FH heterozygotes carrying LDLR-defective or LDLR-negative mutations as well as the effect of ezetimibe monotherapy in 50 hypercholesterolemic (HCH) patients intolerant to statins. PCSK9 and NPC1L1 genes were analysed to assess the role of genetic variants in response to therapy. In FH patients combined therapy reduced LDL-C by 57%,...

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Source

Identifiers

PMID: 17140581
DOI: 10.1016/j.atherosclerosis.2006.10.036

Genes

LDLR
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of ezetimibe coadministered with statins in genotype-confirmed heterozygous FH patients.PMID 17140581Read ↗

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