Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe.

Lipids in health and disease - 12 Aug 2005

Hegele Robert A, Guy Justin, Ban Matthew R, Wang Jian

Abstract excerpt

BACKGROUND: NPC1L1 encodes a putative intestinal sterol transporter which is the likely target for ezetimibe, a new type of lipid-lowering medication. We previously reported rare non-synonymous mutations in NPC1L1 in an individual who had no plasma lipoprotein response to ezetimibe. We next hypothesized that common variants in NPC1L1 would underlie less extreme inter-individual variations in the plasma LDL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azetidines
Share to Cholesterol, LDL
Share to Ezetimibe

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Hypercholesterolemia

Share to Membrane Proteins

Share to Membrane Transport Proteins

Share to Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16098225
DOI: 10.1186/1476-511X-4-16
PMCID: PMC1198250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe.PMID 16098225Read ↗

Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment.Semantic proximity Read ↗

Compound heterozygosity for two non-synonymous polymorphisms in NPC1L1 in a non-responder to ezetimibe.Semantic proximity Read ↗

Common Genetic Variations Involved in the Inter-Individual Variability of Circulating Cholesterol Concentrations in Response to Diets: A Narrative Review of Recent Evidence.Semantic proximity Read ↗

Genetic variation in the cholesterol transporter NPC1L1, ischaemic vascular disease, and gallstone disease.Semantic proximity Read ↗

Using genetics to explore whether the cholesterol-lowering drug ezetimibe may cause an increased risk of cancer.Semantic proximity Read ↗

Gene polymorphism and frequencies of the NPC1L1 gene (rs2072183, rs217434 and rs217428) in Japanese patients with dyslipidemia.Semantic proximity Read ↗

Efficacy of ezetimibe is not related to NPC1L1 gene polymorphisms in a pilot study of Chilean hypercholesterolemic subjects.Semantic proximity Read ↗

The c.-133A > G polymorphism in NPC1L1 gene influences the efficacy of ezetimibe monotherapy on apolipoprotein A1 in hyperlipidemic patients.Semantic proximity Read ↗

Analysis of Niemann-Pick C1-like 1 (NPC1L1) genetic polymorphisms and haplotypes in Chinese Han population.Semantic proximity Read ↗

Genetic variation in ABC G5/G8 and NPC1L1 impact cholesterol response to plant sterols in hypercholesterolemic men.Semantic proximity Read ↗

Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly.Semantic proximity Read ↗

A SNP of NPC1L1 affects cholesterol absorption in Japanese.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.