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Article

Influence of the LDL-Receptor Genotype on Statin Response in Heterozygous Familial Hypercholesterolemia: Insights From the Canadian FH Registry.

The Canadian journal of cardiology - 1 Mar 2022

Roy Gabrielle, Couture Patrick, Genest Jacques, Ruel Isabelle, Baass Alexis, Bergeron Jean, Brisson Diane, Brunham Liam R, Cermakova Lubomira, Gaudet Daniel, Khoury Etienne, Laflamme Nathalie, Kennedy Brooke A, Hegele Robert A, Drouin-Chartier Jean-Philippe

Abstract excerpt

BACKGROUND: Whether low-density lipoprotein (LDL) receptor (LDLR) residual activity influences the LDL-lowering effect of statins in heterozygous familial hypercholesterolemia (HeFH) remains unclear. The objective of this study was to investigate the relationship between the LDLR genotype and statin-induced LDL cholesterol (LDL-C) reductions in HeFH. METHODS: A total of 615 individuals with HeFH...

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Source

Identifiers

PMID: 34774719
DOI: 10.1016/j.cjca.2021.10.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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