Article
Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis.
International archives of allergy and immunology - 1 Jan 2007
Nakamura Hiroyuki, Higashikawa Fumiko, Nobukuni Yoshitaka, Miyagawa Kiyoshi, Endo Tomohiko, Imai Toru, Hatta Kotaro, Ozasa Kotaro, Motohashi Yutaka, Matsuzaki Ichiyo, Sasahara Shinichiro, Ogino Keiki, Akimaru Kunihiro, Eboshida Akira
Abstract excerpt
Whole genome scan analyses have revealed that the chromosomal region 3p21.3, which contains a gene cluster of the CC chemokine receptor, is possibly critical for the pathogenesis of allergic inflammation. Japanese cedar pollinosis is mediated by a type I allergy and induces seasonal rhinitis and conjunctivitis in humans as the most common form of hay fever in spring in Japan, although the candidate genes for...
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