Article
Targeting of p53 and its homolog p73 by protoporphyrin IX.
FEBS letters - 3 Jan 2011
Sznarkowska Alicja, Maleńczyk Katarzyna, Kadziński Leszek, Bielawski Krzysztof P, Banecki Bogdan, Zawacka-Pankau Joanna
Abstract excerpt
The p53 tumor suppressor is recognized as a promising target for anti-cancer therapies. We previously reported that protoporphyrin IX (PpIX) disrupts the p53/murine double minute 2 (MDM2) complex and leads to p53 accumulation and activation of apoptosis in HCT 116 cells. Here we show the direct b...
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