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Article

The N-terminal domain of Bcl-xL reversibly binds membranes in a pH-dependent manner.

Biochemistry - 5 Dec 2006

Thuduppathy Guruvasuthevan R, Terrones Oihana, Craig Jeffrey W, Basañez Gorka, Hill R Blake

Abstract excerpt

Bcl-xL regulates apoptosis by maintaining the integrity of the mitochondrial outer membrane by adopting both soluble and membrane-associated forms. The membrane-associated conformation does not require a conserved, C-terminal transmembrane domain and appears to be inserted into the bilayer of syn...

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Identifiers

PMID: 17128992
DOI: 10.1021/bi0616652
PMCID: PMC1764622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17128992-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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