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Article

Identification of functional domains of Clostridium septicum alpha toxin.

Biochemistry - 5 Dec 2006

Melton-Witt Jody A, Bentsen Lori M, Tweten Rodney K

Abstract excerpt

Alpha toxin (AT) is the major virulence factor of Clostridium septicum that is a proteolytically activated pore-forming toxin that belongs to the aerolysin-like family of toxins. AT is predicted to be a three-domain molecule on the basis of its functional and sequence similarity with aerolysin, for which the crystal structure has been determined. In this study, we have substituted the entire primary structure of...

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Identifiers

PMID: 17128973
DOI: 10.1021/bi061334p
PMCID: PMC2561313

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Source receipt: pubmed, retrieved 7 Sept 2026.

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