Article
Genetics of hand osteoarthritis.
Osteoarthritis and cartilage - 1 Jan 2000
Doherty M
Abstract excerpt
There is convincing epidemiological evidence for a strong hereditary component to hand osteoarthritis (OA). For example: (1) greater concordance for hand OA in monozygotic than in dizygotic twins, the estimated proportion of variance explained by genetic factors being as high as 0.59; and (2) a substantially increased risk of hand OA in first-degree relatives (siblings, parents, offspring) of subjects with hand...
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