Article
Ets-1 participates in and facilitates developmental expression of hypoxia-induced mitogenic factor in mouse lung.
Frontiers in bioscience : a journal and virtual library - 1 Jan 2007
Li Bo, Lager John, Wang Danming, Li Dechun
Abstract excerpt
Hypoxia-induced mitogenic factor (HIMF) possesses mitogenic, vasoconstrictive, angiogenic, and antiapoptotic effects. While HIMF is known to be expressed in developmental mouse lung, its gene expression regulation during this period is completely unknown. Genomic sequencing of HIMF gene has shown that there is an Ets-1 binding site in its 5'-promoter-region. To test the hypothesis that Ets-1 protein expressed in...
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