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Article

Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene

4 Mar 2003

Abstract excerpt

Platelet factor 4 (PF4) is expressed during megakaryocytic differentiation. We previously reported that GATA-1 and ETS-1 regulate the rat PF4 promoter and transactivate the PF4 gene. For the present study, we investigated the regulatory elements and their transcription factors responsible for the lineage-specific expression of the PF4 gene. The promoter activities of deletion constructs were evaluated, and a...

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PMID: 12609849
DOI: 10.1182/blood-2002-02-0380

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Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 genePMID 12609849Read ↗

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