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Article

A bacterial protein enhances the release and efficacy of liposomal cancer drugs.

Science (New York, N.Y.) - 24 Nov 2006

Cheong Ian, Huang Xin, Bettegowda Chetan, Diaz Luis A, Kinzler Kenneth W, Zhou Shibin, Vogelstein Bert

Abstract excerpt

Clostridium novyi-NT is an anaerobic bacterium that can infect hypoxic regions within experimental tumors. Because C. novyi-NT lyses red blood cells, we hypothesized that its membrane-disrupting properties could be exploited to enhance the release of liposome-encapsulated drugs within tumors. Here, we show that treatment of mice bearing large, established tumors with C. novyi-NT plus a single dose of liposomal...

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Identifiers

PMID: 17124324
DOI: 10.1126/science.1130651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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