Article
Salmonella as a biological "Trojan horse" for neoplasia: future possibilities including brain cancer.
Medical hypotheses - 1 Sept 2014
Mlynarczyk Gregory S A, Berg Carrie A, Withrock Isabelle C, Fick Meghan E, Anderson Stephen J, Laboissonniere Lauren A, Jefferson Matthew A, Brewer Matthew T, Stock Matthew L, Lange Jennifer K, Luna K C, Acharya Sreemoyee, Kanuri Sriharsha, Sharma Shaunik, Kondru Naveen C, McCormack Garrett R, Carlson Steve A
Abstract excerpt
This manuscript considers available evidence that a specific Salmonella strain could be used as an effective orally-administered option for cancer therapy involving the brain. It has been established that Salmonella preferentially colonizes neoplastic tissue and thrives as a facultative anaerobe in the intra-tumor environment. Although Salmonella accumulates in tumors by passive processes, it is still possible...
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