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Article

NF-kappaB activation elicited by ionizing radiation is proapoptotic in testis.

Biology of reproduction - 1 Feb 2007

Rasoulpour Reza J, Boekelheide Kim

Abstract excerpt

The transcription factor NF-kappaB modulates apoptotic machinery following activation by the IkappaB kinase (IKK) complex. Inhibiting activity of one of the catalytic subunits of the IKK complex, IKKbeta (also known as IKBKB and IKK2) severely inhibits NF-kappaB nuclear translocation in response to most stimuli, including ionizing radiation. Doubly floxed Ikkbeta(F/F) mice (control) were compared to...

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Identifiers

PMID: 17123945
DOI: 10.1095/biolreprod.106.054924

Genes

IKBKB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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