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Article

DNA Double-Strand Breaks and γ-H2AX Signaling in the Testis1

1 Feb 2003

Abstract excerpt

Within minutes of the induction of DNA double-strand breaks in somatic cells, histone H2AX becomes phosphorylated at serine 139 and forms gamma-H2AX foci at the sites of damage. These foci then play a role in recruiting DNA repair and damage-response factors and changing chromatin structure to accurately repair the damaged DNA. These gamma-H2AX foci appear in response to irradiation and genotoxic stress and...

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PMID: 12533428
DOI: 10.1095/biolreprod.102.008672

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