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Article

The inhibition of aggregation of recombinant human consensus interferon-alpha mutant during Pichia pastoris fermentation.

Applied microbiology and biotechnology - 1 Mar 2007

Hao Yuyou, Chu Ju, Wang Yonghong, Zhuang Yingping, Zhang Siliang

Abstract excerpt

Lower induction temperature and polyoxyethylene sorbitan monolaurate (Tween-20) were successfully used to inhibit the aggregation of recombinant human consensus interferon-alpha mutant (cIFN) during Pichia pastoris fermentation. When the induction temperature was decreased from 30 to 20 degrees C, the cIFN secreted into the medium was in the form of monomers instead of aggregates. The maximum specific activity at...

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PMID: 17123077
DOI: 10.1007/s00253-006-0715-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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