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Article

Incomplete formation of intramolecular disulfide bond triggers degradation and aggregation of human consensus interferon-alpha mutant by Pichia pastoris.

Applied microbiology and biotechnology - 1 Feb 2010

Wu Dan, Ma Dong, Hao Yu-You, Chu Ju, Wang Yong-Hong, Zhuang Ying-Ping, Zhang Si-Liang

Abstract excerpt

Previous study has shown that the degradation and aggregation of recombinant human consensus interferon-alpha mutant (cIFN) were serious when cIFN was secreted to bioreactor by Pichia pastoris. In this study, we showed that this phenomenon was concomitant well with the formation of the doublets o...

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PMID: 19760179
DOI: 10.1007/s00253-009-2232-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19760179-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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