Article
Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function.
American journal of physiology. Renal physiology - 1 Mar 2007
Huang Chunfa, Sindic Aleksandra, Hill Ceredwyn E, Hujer Kristine M, Chan Kim W, Sassen Martin, Wu Zhenzhen, Kurachi Yoshihisa, Nielsen Soren, Romero Michael F, Miller R Tyler
Abstract excerpt
The Ca(2+)-sensing receptor (CaR), a G protein-coupled receptor, is expressed in many epithelial tissues including the parathyroid glands, kidney, and GI tract. Although its role in regulating PTH levels and Ca(2+) metabolism are best characterized, it may also regulate salt and water transport in the kidney as demonstrated by recent reports showing association of potent gain-of-function mutations in the CaR with...
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