Article
Three-dimensional localization of wild-type and myosin II mutant cells during morphogenesis of Dictyostelium.
Developmental biology - 1 Aug 1995
Knecht D A, Shelden E
Abstract excerpt
Dictyostelium amoebae that lack myosin II (mhcA-) are unable to undergo morphogenesis. The cells aggregate slowly to form hemispherical mounds, but the mounds never extend a tip upward. Expression of developmentally regulated genes appears normal in the absence of morphogenesis. When mixed with an excess of wild-type cells, some mutant cells form differentiated spores; however, rescue is extremely inefficient...
Topics
- Animals
- Dictyostelium
- Fluoresceins
- Microscopy, Confocal
- Mutation
- Myosins