Article
The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2006
Semmler Alexander, Simon Matthias, Moskau Susanna, Linnebank Michael
Abstract excerpt
Genetic polymorphisms of methionine metabolism, in particular methionine synthase (MTR) c.2756A>G (D919G) and methylenetetrahydrofolate reductase (MTHFR) c.677C>T (A222V), have been associated with various human cancers. We investigated MTR c.2756A>G, MTHFR c.677C>T, and a third polymorphism, transcobalamin 2 c.776C>G (P259R), for a potential association with the formation of glioblastoma multiforme. The MTR...
Topics
- 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
- Adult
- Aged
- Alleles
- Female
- Folic Acid
- Genetic Predisposition to Disease
- Genetic Variation
- Glioblastoma
- Humans
- Male
- Middle Aged
- Mutation, Missense
- Polymorphism, Genetic
- Vitamin B 12