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Article

Characterization of the cardiac sodium channel SCN5A mutation, N1325S, in single murine ventricular myocytes.

Biochemical and biophysical research communications - 12 Jan 2007

Yong Sandro L, Ni Ying, Zhang Teng, Tester David J, Ackerman Michael J, Wang Qing K

Abstract excerpt

The N(1325)S mutation in the cardiac sodium channel gene SCN5A causes the type-3 long-QT syndrome but the arrhythmogenic trigger associated with N(1325)S has not been characterized. In this study, we investigated the triggers for cardiac events in the expanded N(1325)S family. Among 11 symptomatic patients with document triggers, six died suddenly during sleep or while sitting (bradycardia-induced trigger), three...

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Source

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Identifiers

PMID: 17118339
DOI: 10.1016/j.bbrc.2006.11.019
PMCID: PMC1773013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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