Impact of nevirapine (NVP) plasma concentration on selection of resistant virus in mothers who received single-dose NVP to prevent perinatal human immunodeficiency virus type 1 transmission and persistence of resistant virus in their infected children.

doi:10.1128/AAC.00910-06

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Impact of nevirapine (NVP) plasma concentration on selection of resistant virus in mothers who received single-dose NVP to prevent perinatal human immunodeficiency virus type 1 transmission and persistence of resistant virus in their infected children.

Antimicrobial agents and chemotherapy - 1 Mar 2007

Chaix Marie-Laure, Ekouevi Didier Koumavi, Peytavin Gilles, Rouet François, Tonwe-Gold Besigin, Viho Ida, Bequet Laurence, Amani-Bosse Clarisse, Menan Hervé, Leroy Valériane, Rouzioux Christine, Dabis François

Abstract excerpt

Nonnucleoside reverse transcriptase inhibitor resistance following the use of single-dose nevirapine (sdNVP) for the prevention of mother-to-child transmission (PMTCT) remains a concern. In the ANRS-1201/1202 Ditrame study, conducted in Abidjan, Côte d'Ivoire, a short-course regimen of zidovudine was associated with sdNVP for PMTCT. In this study, we estimate the frequency of NVP resistance and its relationship...

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PMID: 17178792
DOI: 10.1128/AAC.00910-06
PMCID: PMC1803117

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